Eight babies have been born in the UK using genetic material from three people to prevent devastating and often fatal conditions, doctors say.
The method, pioneered by UK scientists, combines the egg and sperm from a mum and dad with a second egg from a donor woman.
The technique has been legal here for a decade but we now have the first proof it is leading to children born free of incurable mitochondrial disease.
These conditions are normally passed from mother to child, starving the body of energy.
This can cause severe disability and some babies die within days of being born. Couples know they are at risk if previous children, family members or the mother has been affected.
Children born through the three-person technique inherit most of their DNA, their genetic blueprint, from their parents, but also get a tiny amount, about 0.1%, from the second woman. This is a change that is passed down the generations.
None of the families who have been through the process are speaking publicly to protect their privacy, but have issued anonymous statements through the Newcastle Fertility Centre where the procedures took place.
'Overwhelmed with gratitude'
"After years of uncertainty this treatment gave us hope - and then it gave us our baby," said the mother of a baby girl.
"We look at them now, full of life and possibility, and we're overwhelmed with gratitude."
The mother of a baby boy added: "Thanks to this incredible advancement and the support we received, our little family is complete.
"The emotional burden of mitochondrial disease has been lifted, and in its place is hope, joy, and deep gratitude."
Mitochondria are tiny structures inside nearly every one of our cells. They are the reason we breathe as they use oxygen to convert food into the form of energy our bodies use as fuel.
Defective mitochondria can leave the body with insufficient energy to keep the heart beating as well as causing brain damage, seizures, blindness, muscle weakness and organ failure.
About one in 5,000 babies are born with mitochondrial disease. The team in Newcastle anticipate there is demand for 20 to 30 babies born through the three-person method each year.
Some parents have faced the agony of having multiple children die from these diseases.
Mitochondria are passed down only from mother to child. So this pioneering fertility technique uses both parents and a woman who donates her healthy mitochondria.
The science was developed more than a decade ago at Newcastle University and the Newcastle upon Tyne Hospitals NHS Foundation Trust and a specialist service opened within the NHS in 2017.
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